Endocrine Abstracts

Background: Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of therapeutic dose of 131I. Unfortunately, administration of radioisotope in diagnostic dose may decrease further radioiodine uptake – the phenomenon called ‘thyroid stunning’. We estimated radiation absorbed dose-dependent changes in genetic material, in particular in sodium iodide symporter (NIS) gene promoter, and NIS protein lev...

Introduction: Dendritic cells (DCs) are considered as main regulators of immune system. Functional properties of DCs depend on their subtype, maturation status, interaction with other immune cells as well as environmental factors including hormones. Recently, we have shown a direct, independent of TSH, regulatory influence of thyroid hormones on human DCs function. The aim of the present study was to analyze ex vivo the effect of systemically administered TSH on human...

Considering, the pivotal role of DC in formation and development of autoimmunological processes, the investigation of influence of of thyrometabolic status on maturation and function of subtypes of human peripheral blood DC, seems to be reasonable and of particular interest. THE AIM of the present study was a complex analysis of the dendritic cell subsets and fenotypes in patients with chronic thyroiditis (ChT) as well as the patients monitored for differentiated thyroid cance...